lansoprazole
Brand: Prevacid
Prototype: omeprazole
Drug Class: proton pump inhibitor
Drug Family: GI agent
Subclass: H+/K+-ATPase inhibitor
Organ Systems: gastrointestinal
Mechanism of Action
Benzimidazole PPI; irreversible proton pump inhibition; available as oral disintegrating tablet.
H+/K+-ATPase
Indications
- GERD
- PUD
- H. pylori
- Zollinger-Ellison
Contraindications
- rilpivirine
- atazanavir
Adverse Effects
Common
- headache
- diarrhea
Serious
- hypomagnesemia
- C. diff
Pharmacokinetics (ADME)
| Absorption | ~80% oral |
| Distribution | moderate |
| Metabolism | hepatic CYP2C19 and CYP3A4 |
| Excretion | renal/fecal |
| Half-life | 1-2 hours |
| Onset | 1-3 hours |
| Peak | 1-2 hours |
| Duration | 24 hours |
| Protein Binding | 97% |
| Vd | 0.5 L/kg |
Drug Interactions
| Drug / Agent | Mechanism | Severity |
|---|---|---|
| clopidogrel | CYP2C19 inhibition | moderate |
Nursing Considerations
- ODT formulation: place on tongue, allow to dissolve — useful when swallowing difficult
- 30-60 min before meals
Clinical Pearls
- Available as orally-disintegrating tablet (Prevacid SoluTab) — useful for NG tubes and patients who cannot swallow
Safety Profile
Pregnancy safe
Lactation use-with-caution
Renal Adjustment Not required
Hepatic Adjustment Required
TDM Not required
Concordance Terms
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